Chemotherapy-related Cognitive Impairment and Acute Leukemia
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Details and patient eligibility
About
This is an ancillary study of an intervention study (NCT04570709). The parent study is a single institution, feasibility trial of 20 (10 control and 10 intervention) patients with the primary objective of assessing feasibility, acceptability, and change in pre and post measures of symptoms, function, and quality of life by administering the Palliative and Collaborative Care InTervention (PACT). We will further assess cognitive function in the patients who participate in the control of the parent study.
Full description
The study objective is to observe patient-reported and researcher-assessed cognitive function in adults with acute myeloid leukemia with chemotherapy treatment. We will assess cognitive function using a battery of neuropsychological assessments, patient-reported questionnaire, and semi-structured interviews among participants in control group only. The group assignment will be conducted through parent study (NCT04570709). Participating in this study will not affect participants' group assignment.
Enrollment
Sex
Ages
Volunteers
Inclusion and exclusion criteria
[Patient]
Inclusion Criteria:
- ≥ 60 years of age
- diagnosis of AML
- Receive 1) low-dose cytarabine or hypomethylating agent (HMA) in combination with Venetoclax chemotherapy OR 2) low-dose cytarabine or hypomethylating agent (HMA) in combination with Venetoclax chemotherapy and any investigational drugs
- have caregiver(s) willing to participate
- participate in the parent study (PACT study, NCT04570709)
Exclusion Criteria:
- referred to hospice care
[Caregiver]
Inclusion criteria:
- identified by patient as a caregiver
- ≥18 years of age
- speak and read English
Trial design
25 participants in 1 patient group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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