Chest Compression and Sustained Inflation

University of Alberta

Status: Completed

Conditions: Newborn Infants Having Asystole or Bradycardia at Birth

Treatments: Procedure: 3:1 CPR; Procedure: CC+SI

Study type: Interventional

Funder types: Other

Identifiers

NCT02083705

Pro00034524_CC

Details and patient eligibility

About

Guidelines on neonatal resuscitation recommend 90 chest compressions (CC) and 30 manual inflations (3:1) per minute in newborns. The study aimed to determine if CC s during sustained inflations (SI) improves recovery of asphyxiated newborns compared to coordinated 3:1 resuscitation.

Enrollment: 9 patients

Sex: All

Ages: Under 3 months old

Volunteers: No Healthy Volunteers

Inclusion criteria

Newborn infants with asystole Newborn infants with bradycardia

Exclusion criteria

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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9 participants in 2 patient groups

SI+CC

Experimental group

Description:

Chest compression will be superimposed by sustained inflations during CPR: "CC+SI group" Infants randomized in the SI group requiring CC, would receive CC at a rate of 90/min during an SI with a duration of 20sec (CC+SI). After 20 sec the SI will be interrupted for 1 sec and the next SI will be started for another 20sec13. Throughout this time CC is continued until ROSC. Every 45 sec (approximately 2 SIs) the clinical team would assess for changes in heart rate. CC+SI was continued until ROSC.

Treatment:

Procedure: CC+SI

3:1 CPR

Active Comparator group

Description:

CPR using 3:1 C:V ratio: "3:1 C:V group" Infants randomized into the "3:1 group" requiring CC, would received CC using the current 3:1 C:V ratio recommend in the neonatal resuscitation guidelines16. Every 45 sec the clinical team would assess heart rate. 3:1 C:V CPR was continued until ROSC.

Treatment:

Procedure: 3:1 CPR