Chewing Clopidogrel in Addition to Regular Oral Clopidogrel Treatment to Improve Platelets Aggregation in Patient With NON ST ELEVATION MI

Sheba Medical Center

Status and phase: Unknown; Phase 3

Conditions: Platlet Aggregation; Major Bleeding Outcomes

Treatments: Drug: clopidogrel by chewing; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT00889044

SHEBA-08 -5397-SM-CTIL

Details and patient eligibility

About

Since the absorption of clopidogrel through the gastrointestinal tract is limited, we want to examine whether adding clopidogrel by chewing will overcome the limited gastrointestinal absorption, and hence will improve the prevention of platelet aggregation.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male and Female older than 18 years old with non-ST myocardial infarction

Exclusion criteria

• Current treatment with anticoagulation medication, any type of cerebro vascular event in the past, active bleeding, active peptic ulcer disease, pregnant women, any inability to sign an informed consent of participate in the study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Quadruple Blind

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30 participants in 2 patient groups, including a placebo group

clopidogrel by chewing

Experimental group

Treatment:

Drug: clopidogrel by chewing

Placebo

Placebo Comparator group

Treatment:

Drug: Placebo