CHildhood ASthma and Environment Research Study - CHASER Study

Stefania La Grutta, MD

Status

Enrolling

Conditions

Asthma

Study type

Observational

Funder types

Other

Identifiers

NCT02433275

8/2014

Details and patient eligibility

About

"CHildhood ASthma and Environment Research study - CHASER study" is an observational longitudinal study in outpatient clinic of Pediatric Allergology & Pulmonology (PAP) of Respiratory Disease Research Center (RDRC) within the Institute of Biomedicine and Molecular Immunology (IBIM) of the National Research Council (CNR) of Palermo (RDRC-IBIM CNR), Italy.

The first phase - transversal study will identify determinants of pediatric asthma control

The second phase - longitudinal study, in patients with persistent asthma, will be focused on:

predictors for asthma exacerbations and loss of control
real life adherence to asthma therapy guidelines
phenotypic characterization through the collection of saliva samples
assessment of alterations and inflammatory changes in the nasal mucosa through nasal brushing
evaluation of the presence of 8-isoprostane, nicotine, cotinine and bisphenol-A through urine analysis.

Chaser Project is expected to improve the knowledge of pediatric asthma in patients with different level of control, identifying predictors for asthma exacerbations and loss of control.

Enrollment

1,600 estimated patients

Sex

All

Ages

5 to 16 years old

Volunteers

No Healthy Volunteers

Inclusion criteria