Childhood Measures of NICU-based Chemical Exposure

Mount Sinai Health System

Status: Withdrawn

Conditions: Development

Study type: Observational

Funder types: Other

Identifiers

NCT02292680

GCO 14-1403

Details and patient eligibility

About

This study aims to identify early life exposures to metals and chemicals by measuring the concentration of metals and organic compounds in shed primary teeth. The researchers will also investigate associations between the presence of these chemicals in teeth and children's social, emotional, and neuro-development.

Full description

Since children begin shedding their primary teeth around age 6, the investigators will enroll children who will be turning 6 in the next two years. First, the investigators will follow up with the children's development by conducting a battery of non-invasive neurodevelopmental tests. Also, the parents will be asked to complete a questionnaire called the Child Behavior Checklist, which assesses behavioral problems. Then, each child's parent will be asked to send the research team 2-3 teeth that their child has shed, or to send teeth as they are shed over the next three years. Dr. Stroustrup's collaborator, Dr. Manish Arora, will perform a temporal analysis of chemical distribution for each tooth to determine each child's environmental exposures during the perinatal and neonatal periods.

Sex: All

Ages: 4 to 6 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 4-6 years of age in 2014 (six years of age by the end of 2016)
• Cared for as a neonate in Mount Sinai's NICU

Exclusion criteria

• Parent documented in Mount Sinai's database is no longer the legal guardian
• Non-English-speaking parents

Trial design

0 participants in 1 patient group

NICU Tooth Study Cohort

Description:

All study subjects will have been cared for in the Mount Sinai NICU and have had the same hospital environment exposure.