Children Acceptance of AgNP Mouthwash Against Chlorhexidine Mouthwash

Cairo University (CU)

Status: Not yet enrolling

Conditions: Numbness of the Tongue and Soft Tissue; Bitter Taste; Teeth Staining

Treatments: Other: Chlorhexidine mouthwash (0.12%); Other: nano silver mouthwash; Other: Chlorhexidine mouthwash (0.2%)

Study type: Interventional

Funder types: Other

Identifiers

NCT07200063

AgNP vs CHX Mouthwashes

Details and patient eligibility

About

This study aims to evaluate and compare the children's acceptance of mouthwash containing silver nanoparticles versus Chlorhexidine.

Full description

Effective management of dental plaque is crucial for preventing periodontal diseases, dental caries, and other oral health complications. Oral hygiene can be maintained through both chemical and mechanical methods. Chemical methods are particularly beneficial in situations where mechanical cleaning proves challenging. Mouthwashes represent a significant chemical strategy for controlling plaque. Among different types of mouthwashes, chlorhexidine is considered the gold standard due to its high efficacy against a broad spectrum of bacteria and its role in plaque management, which helps prevent periodontal diseases. However, it is important to note that chlorhexidine has several side effects, such as numbness, changes in taste perception, dental staining, and an unpleasant bitter taste.

In modern applications, nanotechnology is being utilized more frequently, especially with the integration of nanoparticle materials. Silver nanoparticles, in particular, are widely used in the medical field because of their remarkable antibacterial effects on oral biofilms associated with periodontal disease.

Therefore, this research aims to evaluate the children's acceptance of chlorhexidine mouthwash in children compared to a mouthwash containing silver nanoparticles, as well as to assess their respective impacts on gingivitis.

Enrollment: 60 estimated patients

Sex: All

Ages: 6 to 12 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria

• Children aged from 6 to 12 in good general health and medically free
• Cooperative patient who will care about attending the follow-up visit
• Acceptance of the parents to sign the informed consent
• Composite restoration on anterior teeth Exclusion criteria
• Children who are unable to attend the follow-up visit
• Medically compromised patient
• Handi-capped patient
• Parents refuse to sign informed consent

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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60 participants in 3 patient groups

use AgNP mouthwash as experimental group

Experimental group

Description:

nano cure mouthwash

Treatment:

Other: nano silver mouthwash

use hexitol mouthwash (CHX) as experimental group

Experimental group

Treatment:

Other: Chlorhexidine mouthwash (0.12%)

orovex mouthwash (CHX) as a comparator group

Active Comparator group

Treatment:

Other: Chlorhexidine mouthwash (0.2%)