Child's Study of the Impact of PF Lesion on Motor Skills, Language, Cognitive Functioning and Social Cognition (CervIRM)

University Hospital, Angers

Status: Unknown

Conditions: Fossa Posterior Tumor; Low-grade Glioma; Healthy Volunteers; Medulloblastoma, Childhood

Treatments: Other: Functional Magnetic Resonance Imaging (fMRI)

Study type: Observational

Funder types: Other

Identifiers

NCT04174820

49RC18_0010

Details and patient eligibility

About

One of the major complications of posterior fossa surgery is Posterior Fossa Syndrome (PFS). This syndrome is due to a possible complication of surgical excision of a tumor of the cerebellum (4th ventricle) and is characterized by transient postoperative mutism, dysarthria, behavioral, and affective disorders, as well as motor disorders. PFS is thought to be related to axonal lesions. The long-term consequences on the cognitive and psychosocial sphere of PFS have been widely documented. On the other hand, the literature concerning the consequences of this syndrome on language is much restricted. Beyond the language, the role of cerebellum would be central in cognition, some authors even comparing it to a great "conductor" who would underlie the learning of most motor and cognitive automatisms.

Full description

The physiopathology and the anatomo-functional correlates of motor, cognitive, and language functions after surgery of PF tumors are still rare and little known. The objective of this study is to analyze them via morphometric MRI analysis and functional and structural connectivity in children away from PF surgery, coupled with clinical data analysis.

Enrollment: 145 estimated patients

Sex: All

Ages: 6 to 17 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patient with a low grade glioma of the posterior fossa or a medulloblastoma
• Healthy volunteers without any tumor in the posterior fossa (control case)
• At one year of the last treatment for the retrospective groups, or patient who have an indication to a surgery of a tumor of the posterior fossa
• Eligibility to a functional MRI
• Informed consent dated and signed by the holder of the parental authority (if minor) or by the patient (if major) to take part in the study
• Affiliated to a Social Security scheme

Exclusion criteria

• Antecedent of neurologic, metabolic or genetic disease
• Brainstem glioma
• Have a contraindication to a MRI

Trial design

145 participants in 4 patient groups

Retrospective Low-Grade Glioma

Description:

Inclusion of patients with Low-Grade Glioma treated one year ago, with functional Magnetic Resonance Imaging, speech therapy, neuropsychological, balance and dexterity tests

Treatment:

Other: Functional Magnetic Resonance Imaging (fMRI)

Retrospective Medulloblastoma

Description:

Inclusion of patients with Medulloblastoma treated one year ago, with functional Magnetic Resonance Imaging, speech therapy, neuropsychological, balance and dexterity tests

Treatment:

Other: Functional Magnetic Resonance Imaging (fMRI)

Prospective patients

Description:

Inclusion of prospective patients with an indication to surgery of a Posterior Fossa Tumor, with evaluation of post-operative mutism and then one year after the end of mutism, an evaluation with functional Magnetic Resonance Imaging, speech therapy, neuropsychological, balance and dexterity tests

Treatment:

Other: Functional Magnetic Resonance Imaging (fMRI)

Control patients

Description:

Inclusion of patients without Posterior Fossa Tumor, with functional Magnetic Resonance Imaging, speech therapy, neuropsychological, balance and dexterity tests

Treatment:

Other: Functional Magnetic Resonance Imaging (fMRI)