China Atrial Fibrillation With Complex Metabolic Disorder Cohort Study (CAME Cohort)

Central South University

Status: Not yet enrolling

Conditions: Metabolic Disorders; Atrial Fibrillation (AF)

Study type: Observational

Funder types: Other

Identifiers

NCT07309913

2025101847

Details and patient eligibility

About

The number of atrial fibrillation (AF) patients in China is approximately 32.76 million, with a prevalence rate of 2.3%. AF is associated with severe outcomes such as stroke and heart failure. Metabolic disorders (e.g., obesity, diabetes mellitus, dyslipidemia) are closely linked to the onset and prognosis of AF. However, the epidemiological characteristics and disease burden of AF combined with metabolic disorders in China remain unclear. Additionally, the impact of complex multi-dimensional metabolic disorders on AF prognosis requires further investigation, and current clinical guidelines lack targeted management recommendations for this population.

Enrollment: 3,459 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

• Meet the diagnostic criteria for atrial fibrillation: Single-lead electrocardiogram (≥30 seconds) or 12-lead electrocardiogram (≥10 seconds) shows disappearance of P waves, replaced by fibrillation waves (f waves) with irregular amplitude, morphology and duration, and absolutely irregular RR intervals.
• Aged ≥ 18 years.
• Willing to sign the informed consent form and cooperate with long-term follow-up.

Exclusion Criteria

• Suffering from infective endocarditis or myocarditis.
• Having clear etiological factors of atrial fibrillation caused by hyperthyroidism, and the etiology has not been effectively controlled.
• Suffering from severe mental illness and being unable to comply with the study requirements.
• Pregnant women.
• Patients with malignant tumors or substance abuse (e.g., cocaine, heroin).

Trial design

3,459 participants in 3 patient groups

No metabolic disorder

Single metabolic disorder

Complex metabolic disorder (≥2 types)