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The aim of this study is to establish and perfect the China Cognition and Aging Study (China COAST) cohort, to clarify the epidemiology, influencing factors, genetic characteristics, pathogenesis, disease characteristics and diagnosis and treatment status of dementia and its subtypes in China. It is of great significance to establish a relatively comprehensive national database of cognitive disorders, improve the clinical diagnosis and treatment level of cognitive disorders, and formulate prevention and treatment strategies for dementia. The primary aims of China COAST are as follows:
Full description
This study involved participants including Mild cognitive impairment (MCI) and its subtypes、Sporadic Alzheimer's disease (SAD)、 Familial Alzheimer's disease (FAD)、Vascular dementia (VaD)、Normal control in community population and hospital population. Research contents are as follow:
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Inclusion and exclusion criteria
Community population: age ≥ 55 years, male or female, with consent to participant the study.
Hospital population: subjects are all over 18 years old. Through clinical evaluation, neuropsychological test, imaging examination, blood and cerebrospinal fluid examination, etc, we will comprehensively evaluate the cognitive function and various test measures.
(1) MCI and its subtypes
Inclusion criteria:
Exclusion criteria:
(2) Sporadic Alzheimer's disease (SAD)
Inclusion criteria:
Exclusion criteria:
(3) Familial Alzheimer's disease (FAD)
Inclusion criteria:
Exclusion criteria:
(4) Vascular dementia (VaD)
Inclusion criteria:
Diagnosis for probable VaD according to NINDS-AIREN diagnostic criteria.
MRI inclusion criteria:
All patients who meet clinical inclusion criteria should accept MRI scans which include an assessment of hippocampal volume.
Exclusion criteria:
(5) Normal control
Inclusion criteria:
Exclusion criteria:
100,000 participants in 6 patient groups
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Central trial contact
Jianping Jia, Doctor
Data sourced from clinicaltrials.gov
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