Chitosan and i-PRF in Palatal Wound Healing

Biruni University

Status: Completed

Conditions: i-PRF; Chitosan; Wound Healing; Free Gingival Graft

Treatments: Procedure: free gingival graft + chitosan; Procedure: free gingival graft + gelatin sponge; Procedure: free gingival graft + chitosan and i-PRF

Study type: Interventional

Funder types: Other

Identifiers

NCT07072546

Chitosan-iPRF

Details and patient eligibility

About

This study aims to evaluate the effects of chitosan and injectable platelet-rich fibrin (i-PRF) on wound healing at the donor site following free gingival graft (FGG) procedures. The palatal donor area often experiences delayed healing and postoperative discomfort, motivating the search for effective biomaterials to enhance recovery and reduce patient morbidity. Although various approaches have been investigated, the combined application of chitosan and i-PRF has not yet been explored in this context.

The study examines three patient groups treated at the periodontology departments of Çukurova and Biruni University: one with gelatin sponge (control), one with chitosan, and one with chitosan infused with i-PRF. Parameters such as pain (VAS), bleeding, burning sensation, dietary changes, epithelialization (PEHI score), and color match were assessed over a 2-month follow-up.

The findings are expected to provide insights into whether i-PRF-enhanced chitosan offers superior healing outcomes and greater patient comfort compared to conventional methods.

Enrollment: 68 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Periodontally healthy
• Having good oral hygiene (plaque accumulation <20%)
• Requiring a free gingival graft (FGG) procedure in an area with insufficient keratinized gingiva width (<2 mm)

Exclusion criteria

• Having systemic diseases contraindicating surgical procedures,
• Uncontrolled diabetes (HbA1c > 7),
• Being pregnant or breastfeeding,
• Autoimmune and/or inflammatory diseases of the oral cavity,
• Active periodontal disease,
• Smokers (≥ 10 cigarettes per day)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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68 participants in 3 patient groups

control

Other group

Description:

control group

Treatment:

Procedure: free gingival graft + gelatin sponge

chitosan

Active Comparator group

Treatment:

Procedure: free gingival graft + chitosan

chitosan-iprf

Experimental group

Treatment:

Procedure: free gingival graft + chitosan and i-PRF