Chitosan Versus Glucosamine Phonophoresis in the Management of Knee Osteoarthritis

October 6 University

Status: Active, not recruiting

Conditions: Knee Arthritis; Knee Osteoarthritis

Treatments: Procedure: Conventional Physical Therapy; Device: Phonophoresis with glucoasmine; Device: Phonophoresis with chitosan

Study type: Interventional

Funder types: Other

Identifiers

NCT05420441

ChPhono2022

Details and patient eligibility

About

The study will be conducted to answer the following questions:

• Is there an effect of phonophoresis using glucosamine on pain level , function and range of motion in knee osteoarthritis patients ?
• Is there an effect of phonophoresis using chitosan on pain level , function and range of motion in knee osteoarthritis patients ?
• Is there a difference between the effect of phonophoresis using glucosamine and phonophoresis using chitosan on pain level , function and range of motion in knee osteoarthritis patients ?

Enrollment: 60 patients

Sex: All

Ages: 45 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• unilateral or bilateral grade II knee osteoarthritis (clinical and imaging diagnosis X-ray).
• knee pain intensity ≥ 5 on the Visual Analogue Scale (VAS)

Exclusion criteria

• Anterior Cruciate Ligament (ACL) and meniscus injury
• use of oral or injected corticosteroids in the last 3 months
• history of knee surgery or fracture
• acute infectious synovitis or arthritis conditions
• presence of malignancy
• individuals with, topical lesions, contact dermatitis and history of cutaneous hypersensitivity

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 3 patient groups

Group A (Phonophoresis with chitosan group)

Experimental group

Description:

Patients in this group will receive chitosan through phonophoresis plus conventional treatment. For the phonophoresis parameters: pulsed ultrasonic waves (25%) of 1 MHz frequency and 1 W/cm2 intensity applied with a 5 cm diameter transducer. The total time of ultrasound application was eight minutes.Patients will also receive conventional Physical therapy program

Treatment:

Procedure: Conventional Physical Therapy

Device: Phonophoresis with chitosan

Group B (Phonophoresis with glucosamine group)

Experimental group

Description:

Patients in this group will receive glucosamine through phonophoresis plus conventional treatment. For the phonophoresis parameters: pulsed ultrasonic waves (25%) of 1 MHz frequency and 1 W/cm2 intensity applied with a 5 cm diameter transducer. The total time of ultrasound application was eight minutes.Patients will also receive conventional Physical therapy program.

Treatment:

Procedure: Conventional Physical Therapy

Device: Phonophoresis with glucoasmine

Group C (Conventional physical therapy only)

Active Comparator group

Description:

Patients in the control group will receive the conventional treatment for knee osteoarthritis only, which will include the application of TENS, pulsed ultrasound, infrared light and exercise.

Treatment:

Procedure: Conventional Physical Therapy