Chlamydia and Mycoplasma in Coronary Artery Disease

Hospital de Base

Status: Completed

Conditions: Coronary Artery Disease; Mycoplasma Infections; Chlamydia Infections; Atherosclerosis

Treatments: Other: blood sample analysis - mycoplasma and chlamydia antibodies

Study type: Observational

Funder types: Other

Identifiers

NCT00561028

5105/2001

885/02

Details and patient eligibility

About

To test the association between anti-Chlamydia serum titers and anti-Mycoplasma antibodies with Acute Coronary Syndromes.

Full description

One hundred and twenty-six patients were divided into 4 groups: Acute Coronary Syndrome with ST-elevation, Non-ST-elevation, stable coronary artery disease, and individuals without coronary disease. Anti-Chlamydia and anti-Mycoplasma IgG antibodies were measured at baseline and after 6 months.

Enrollment: 138 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age >18 yrs
• Males and females
• Agreed to sign the informed consent

Exclusion criteria

• Refusal to sign the informed consent
• Follow-up not possible
• For the "acute" groups, time between the pain beginning and randomization >24 hours
• Active infections
• Use of antimicrobial agents within the last 30 days
• End-stage diseases with life expectancy <6 months

Trial design

138 participants in 4 patient groups

1

Description:

ST-elevation acute myocardial infarction.

Treatment:

Other: blood sample analysis - mycoplasma and chlamydia antibodies

2

Description:

high-risk unstable angina or non-ST-elevation myocardial infarction.

Treatment:

Other: blood sample analysis - mycoplasma and chlamydia antibodies

3

Description:

known coronary artery disease, either asymptomatic or with stable angina.

Treatment:

Other: blood sample analysis - mycoplasma and chlamydia antibodies

4

Description:

blood donors without known coronary artery disease.

Treatment:

Other: blood sample analysis - mycoplasma and chlamydia antibodies