Chlorhexidine Bathing to Prevent Hospital-acquired Infections: the CLEANS Study

Fudan University

Status: Unknown

Conditions: Surgery; Hospital-Acquired Infection; Intensive Care Unit; Chlorhexidine

Treatments: Other: 2% Chlorhexidine bathing

Study type: Interventional

Funder types: Other

Identifiers

NCT05142969

2020ZSLC69

Details and patient eligibility

About

Hospital-acquired infections (HAI) have been shown to increase length of hospital stay and mortality. Infections acquired during a hospital stay have been shown to be preventable. The skin of patients is considered a major reservoir for pathogens associated with hospital-acquired infections, and has been suggested as a potential target for interventions to reduce bacterial burden and subsequent risk of infection. The use of daily Chlorhexidine (CHG) bathing in intensive care patients has been advocated to reduce many of the infections in critically ill patients. However, the effectiveness of CHG bathing to reduce ICU infections has varied considerably among published trials, making the effectiveness of CHG bathing in ICU patients uncertain.

Enrollment: 247 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adults (≥ 18-years old)
• anticipated SICU stay for 48 hours or more
• APACHE II >15

Exclusion criteria

• Braden Scale for Predicting Pressure Sore Risk score more than 9 (highest risk)
• pregnancy
• skin irritation
• chlorhexidine allergy
• SICU stay of more than 48 hours prior to screening

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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247 participants in 2 patient groups

Control arm

No Intervention group

Description:

Patients were daily bathed with soap and water only.

Intervention arm

Experimental group

Description:

Patients were daily bathed with soap and water and then receive 2% Chlorhexidine bathing (Petel Skin care wipes, Likang LtD, shanghai, China).

Treatment:

Other: 2% Chlorhexidine bathing