Chloride High Level Of Resuscitation Infusion Chloride High Level Of Resuscitation Infusion Delivered Evaluation (CHLORIDE)

Austin Health

Status and phase

Unknown

Phase 4

Conditions

Shock

Critical Illness

Treatments

Drug: Lower chloride fluids (Hartmann's solution and Plasmalyte®)

Study type

Interventional

Funder types

Other

Identifiers

NCT00885404

2008/03445

Details and patient eligibility

About

The purpose of this study is to determine whether intravenous fluid management using lower chloride solutions (Hartmann's solutions and Plasmalyte®) will result in better outcome when compared to management using high chloride solutions (0.9% saline and Gelofusine®).

Full description

This is a prospective, controlled, before-and-after study. The baseline pre-intervention period will include collection of data while doctors and nurses are unaware that such collection is taking place. During this time, high chloride fluids (saline, Gelofusine, 4% albumin) will continue to be used according to standard practice with an estimated 30,000 liters of saline as well as 2,000 bottles of Gelofusine® being consumed.

Following a wash out period of education and preparation, there will be a complete shift to a working environment where use of saline, Gelofusine and any other fluids with a high chloride level (>110 mmol/L)will be restricted and substituted with fluids of lower chloride concentration similar to blood; either Hartmann's solution or Plasmalyte® or 20% albumin.

The study will compare a 6 month control period (before) and a six month intervention period (after).

Enrollment

7,000 estimated patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

All Intensive Care Unit (ICU) admissions at Austin Hospital
All Emergency Department (ED) admissions at Austin Hospital
All operations at Operating Theatre (OT) with hospital stay of more than 48 hours

Exclusion Criteria: Nil