Chloroprocaine Spinal for Outpatient Knee Surgery

Hospital for Special Surgery (HSS) logo

Hospital for Special Surgery (HSS)

Status and phase

Terminated
Phase 2

Conditions

Knee Arthroscopy

Treatments

Drug: General Anesthetics
Drug: Chloroprocaine
Drug: Mepivacaine

Study type

Interventional

Funder types

Other

Identifiers

NCT03365752
2017-1547

Details and patient eligibility

About

Outpatient knee surgeries with duration of less than one hour pose a challenge to the use of spinal anesthesia given that traditional agents remain in effect for 2-3 hours, thus creating a mismatch between length of surgery and anesthetic resolution. The investigators hypothesize that the use of chloroprocaine can combine the benefits of a short spinal anesthetic while avoiding the side effects of a general anesthetic, thus promoting earlier discharge.

Enrollment

39 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients scheduled for a knee arthroscopy that is anticipated to be less than one hour
  • Age 18 to 80 years
  • Ability to follow study protocol
  • English speaking

Exclusion criteria

  • Hepatic or renal insufficiency
  • Younger than 18 years old and older than 80
  • Allergy or intolerance to one of the study medications
  • Chronic gabapentin/pregabalin use (regular use for longer than 3 months)
  • Chronic opioid use (taking opioids for longer than 3 months)
  • Patients unable to undergo a spinal anesthetic or Laryngeal Mask Airway (LMA)/GA or patient refusal to spinal anesthesia or LMA/GA

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

39 participants in 3 patient groups

Chloroprocaine
Experimental group
Treatment:
Drug: Chloroprocaine
Mepivacaine
Active Comparator group
Treatment:
Drug: Mepivacaine
General Anesthesia
Active Comparator group
Treatment:
Drug: General Anesthetics

Trial documents
1

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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