Chloroprocaine Spinal for Outpatient Knee Surgery

Hospital for Special Surgery (HSS)

Status and phase: Terminated; Phase 2

Conditions: Knee Arthroscopy

Treatments: Drug: General Anesthetics; Drug: Chloroprocaine; Drug: Mepivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT03365752

2017-1547

Details and patient eligibility

About

Outpatient knee surgeries with duration of less than one hour pose a challenge to the use of spinal anesthesia given that traditional agents remain in effect for 2-3 hours, thus creating a mismatch between length of surgery and anesthetic resolution. The investigators hypothesize that the use of chloroprocaine can combine the benefits of a short spinal anesthetic while avoiding the side effects of a general anesthetic, thus promoting earlier discharge.

Enrollment: 39 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled for a knee arthroscopy that is anticipated to be less than one hour
• Age 18 to 80 years
• Ability to follow study protocol
• English speaking

Exclusion criteria

• Hepatic or renal insufficiency
• Younger than 18 years old and older than 80
• Allergy or intolerance to one of the study medications
• Chronic gabapentin/pregabalin use (regular use for longer than 3 months)
• Chronic opioid use (taking opioids for longer than 3 months)
• Patients unable to undergo a spinal anesthetic or Laryngeal Mask Airway (LMA)/GA or patient refusal to spinal anesthesia or LMA/GA

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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39 participants in 3 patient groups

Chloroprocaine

Experimental group

Treatment:

Drug: Chloroprocaine

Mepivacaine

Active Comparator group

Treatment:

Drug: Mepivacaine

General Anesthesia

Active Comparator group

Treatment:

Drug: General Anesthetics