CHO-loading Before and High Intermittent CHO-intake During Physical Exercise in T1D

Örebro University, Sweden

Status: Completed

Conditions: Diabetes Mellitus, Type 1

Treatments: Other: Carbohydrate loading and high intermittent carbohydrate intake during physical exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT03722225

Dnr:2012/159

Details and patient eligibility

About

Prolonged physical exercise (PE) is a challenge in type 1 diabetes with an increased incidence of both hypoglycemia and hyperglycemia.

The purpose was to evaluate the impact of two consecutive days of carbohydrate (CHO) loading, followed by high intermittent CHO-intake during prolonged PE, facilitated by a proactive use of Real-Time Continuous Glucose Monitoring (rtCGM), on glucose control in individuals with type 1 diabetes.

Ten physically active individuals with type 1 diabetes were invited to participate in a 3-day long sports camp with the objective to evaluate CHO-loading and high intermittent CHO-intake during prolonged PE. 1.5 months later the same procedure was evaluated during a 90 km cross-country skiing race. Participants were instructed to act proactively using rtCGM with predictive alerts set for high and low glucose values to maintain sensor glucose values within target range, defined as 72-180 mg/dl (4-10 mmol/l).

Full description

This is a descriptive, single arm, non-randomized interventional study. The intervention consisted of carbohydrate loading prior to and intermittent high carbohydrate intake during physical exercise and a proactive use of Real-Time Continuous Glucose Monitoring (rtCGM) to achieve and maintain glucose control.

Central Contact Person Stig A Mattsson, dietician PhD student Phone: [phone] E-mail: [e-mail]

IPD Sharing Statement No: There is not a plan to make IPD available.

Enrollment: 10 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 18-50 years
• type 1 diabetes
• diabetes duration >1 year
• exercising regularly ≥3 workout/week
• previous experience from cross-country skiing

Exclusion criteria

• A1c 8.6% NGSP (70 mmol/mol IFCC)
• proliferative retinopathy
• known nephropathy
• cardiac failure
• following a low-carbohydrate diet.

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Descriptive, single arm, interventional study

Experimental group

Description:

The intervention consisted of carbohydrate loading prior to and intermittent high carbohydrate intake during physical exercise and a proactive use of Real-Time Continuous Glucose Monitoring (rtCGM) to achieve and maintain glucose control

Treatment:

Other: Carbohydrate loading and high intermittent carbohydrate intake during physical exercise