Choline Quantification in Breast Cancer by MRS

Norwegian University of Science and Technology

Status

Withdrawn

Conditions

Breast Neoplasms

Study type

Observational

Funder types

Other

Identifiers

NCT00201487

11870

Details and patient eligibility

About

Choline has been found in increased concentration in breast cancer patients. Hypothesis: The choline signal as observed by MRS is sensitive to treatment, and a positive response to treatment will give a reduction in choline concentration.

The purpose of this study is to establish methods for quantification of choline in breast cancer by MRS

Full description

Establishment of new MRS sequence for choline quantification of choline. This sequence is choline-selective, and signals from water and lipids are suppressed simultaneously.
Compare to different methods for choline quantification. The first method is quantification through an external phantom standard, containing a known concentration of choline. The other method is based on the utilisation of internal water signal as a reference.

Both calculations can be performed from the same MR exam. Ten patients will be included in the study.

Sex

Female

Ages

20+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria