Chongqing Primary Aldosteronism Study

Chongqing Medical University

Status: Enrolling

Conditions: Primary Aldosteronism

Treatments: Other: no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT03224312

CONPASS

Details and patient eligibility

About

We intends to conduct a series of original clinical research about PA, and establish a large cohort of PA and essential hypertension patients with long-term follow-up of cardiovascular events, renal end points etc. We will establish a large sample of blood, urine, adrenal tissue of the subjects, and the genomics,metabonomics, proteomics database, to explore the mechanism of the PA and target organ damage, risk factors, diagnostic methods and biomarkers.

Full description

This study will include the subjects of a series of studies on hypertension conducted by our team, including essential hypertension, PA subjects, and establish a large sample database and specimen bank through follow-up and omics analysis.

Enrollment: 1,500 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. hypertensive patients who completed ARR screening and necessary further tests;
2. Voluntary to sign the informed consent.

Exclusion criteria

1. patients with severe cardiac, hepatic or renal dysfunction;
2. suspicious or confirmed other types of secondary hypertension, including Cushing's syndrome, pheochromocytoma and renal artery stenosis et al.

Trial design

1,500 participants in 2 patient groups

Primary aldosteronism

Description:

screened, confirmed and subtyped according to the guidelines.

Treatment:

Other: no intervention

Essential hypertension

Description:

screened for PA and excluded the diagnosis of PA as well as other secondary hypertesion

Treatment:

Other: no intervention