Choosing the Right Pacing Mode in Heart Failure - The CHOICE Trial

University of Dundee

Status: Completed

Conditions: Heart Failure

Treatments: Device: Bi Ventricular Pacing; Device: Right Ventricular Pacing

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00875732

ELD001

Details and patient eligibility

About

The aim of the study is to see if biventricular pacemakers offer any advantage over conventional pacemakers in patients with heart failure who require pacemakers. The endpoints will be the 6 minute walking distance along with markers of cardiovascular function.

The investigators' hypothesis is that biventricular pacing is preferable to conventional pacing in these heart failure patients.

Enrollment: 22 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Left ventricular systolic dysfunction.
2. Atrio-ventricular node disease.
3. Anticipated to be more than 40% paced, (including patients in permanent atrial fibrillation).
4. Ability to walk independently (walking aid permitted).

Exclusion criteria

1. Patients meeting criteria for CRT by current guidelines will be excluded.
2. Life expectancy less than12 months.
3. Inability to walk independently.
4. Patients not likely to be compliant with follow-up.
5. Bradyarrhythmia due with sino-atrial disease only.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

---

22 participants in 2 patient groups

1

Experimental group

Description:

Biventricular Pacing

Treatment:

Device: Bi Ventricular Pacing

2

Active Comparator group

Description:

Right Ventricular Pacing

Treatment:

Device: Right Ventricular Pacing