Chorioamnionitis and Proinflammatory S100A12

Catholic University of the Sacred Heart

Status: Completed

Conditions: Chorioamnionitis Affecting Fetus or Newborn

Study type: Observational

Funder types: Other

Identifiers

NCT02996279

100093

Details and patient eligibility

About

Histologic chorioamnionitis (HCA) may lead to the fetal inflammatory response syndrome (FIRS) and increased levels of proinflammatory molecules.

Full description

Histologic chorioamnionitis (HCA) may lead to the fetal inflammatory response syndrome (FIRS). The aim of this pilot study was to evaluate S100A12, a marker of innate immune activation, in mothers with or without HCA and in their infants.

Concentrations of S100A12, Interleukin 6 (IL-6) and C-reactive protein (CRP) were evaluated in maternal, cord, and neonatal blood of very preterm infants. Histologic examinations of placentae and umbilical cords were performed.

Enrollment: 69 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

Preterm Birth

Exclusion criteria

Congenital Abnormalities

Trial design

69 participants in 2 patient groups

group 1

Description:

maternal chorioamnionitis

group 2

Description:

no maternal chorioamnionitis