Choroidal Change on OCTA in Eyes With High Myopia

Nanjing Medical University

Status: Not yet enrolling

Conditions: Choroid Disease; Myopia, Progressive

Treatments: Device: Optic coherence tomography angiography (OCTA)

Study type: Interventional

Funder types: Other

Identifiers

NCT04255524

OCTAPPA

Details and patient eligibility

About

Myopia is a global healthy concern, especially the high myopia and pathological myopia among Asian populations. However, its mechanism still remains largely unclear. Recent findings suggested choroidal changes might be related to the development of myopia. This study is to useOCT angiography (OCT-A) to investigate parapapillary choroidal microvasculature change in myopic eyes, and try to find the cause-and-effect relationship between choroidal change and the development of myopia.

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Spherical equivalent measurement can be included in above 4 groups
2. Willing to be followed up in the future 10 years

Exclusion criteria

1. Deny to sign the patient consent, or deny to be followed
2. Evidence of cardiac, or diabetic, or CNS disease.
3. Clinically diagnosed with retinal or choroidal disease
4. Glucoma
5. Cataract or corneal disease that influence the quality of fundus OCTA image

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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200 participants in 4 patient groups

Group 1/Control

Experimental group

Description:

Spherical equivalent: -2.00～+2.00 D

Treatment:

Device: Optic coherence tomography angiography (OCTA)

Group 1/Myopia

Experimental group

Description:

Spherical equivalent: -3.00～-6.00 D

Treatment:

Device: Optic coherence tomography angiography (OCTA)

Group 3/High

Experimental group

Description:

Spherical equivalent: -6.00～-10.00 D

Treatment:

Device: Optic coherence tomography angiography (OCTA)

Group 4/Super High

Experimental group

Description:

Spherical equivalent: \<-10.00

Treatment:

Device: Optic coherence tomography angiography (OCTA)