CHROENDOHNPCC: Early Detection of Pre-cancer Lesions in Adults With Hereditary Nonpolyposis Colorectal Cancer Syndrome

Assistance Publique - Hôpitaux de Paris

Status and phase

Completed

Phase 2

Conditions

Colorectal Neoplasms, Hereditary Nonpolyposis

Treatments

Procedure: Colonoscopy with chromoscopy

Study type

Interventional

Funder types

Other

Identifiers

NCT00224601

P040423

Details and patient eligibility

About

The aim of the study is to test the hypothesis that a chromoscopy colonoscopy is able to increase by 50 % the number of pre-cancer lesions or early cancer detected in patients with HNPCC syndrome, compared to a routine colonoscopy without chromoscopy.

Full description

Patient with HNPCC syndrome confirmed by a mutation (MLH1, MSH2, MHS1) are involved in the study. Patient have 2 colonoscopy back to back. The second coloscopy is associated to chromoscopy with carmin indigo. Endoscopist are randomised for the colonoscopy with chromoscopy and are un-awarded of the result of the first colonoscopy. Histopathology of the polyp are noted. The follow up were 1 month.

Enrollment

80 patients

Sex

All

Ages

25 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with MLH1, MSH2 or MSH6 mutation.
Patients concerned by early detection colonoscopy.

Exclusion criteria

Coloscopy of tracking since less 1an
occlusive Syndrome contra-indicating the preparation for a total coloscopies
Colectomies
medical Conditions or serious illnesses contra-indicating a coloscopy of screening
pregnant Woman or nursing
Anomaly of coagulation contra-indicating the realization of biopsies and/or the exeresis of the lesion colorectal