Chromocolonoscopy for the Detection of Flat Adenomas in Routine Colorectal Cancer Screening.
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About
The proposed research aims to determine the prevalence, size, shape and histology of flat colorectal neoplasms in a cohort of asymptomatic, average-risk individuals presenting for screening colonoscopy. Patients will be randomized to either conventional colonoscopy or chromocolonoscopy, where the entire colon will be sprayed with indigocarmine dye and examined in the usual manner. The primary outcome will be the total number of adenomas detected, with special attention to the subgroup of flat and depressed lesions. To promote the generalizability of the results, neoplasms will be described according to standard Western and Japanese classification schemes.
Enrollment
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Volunteers
Inclusion criteria
- Patients undergoing screening colonoscopy
Exclusion criteria
- Age < 50
- Prior colon resection
- Inflammatory bowel disease
- Prior colonoscopy or sigmoidoscopy
- More than one first-degree relative with colon cancer
Trial design
Primary purpose
Allocation
Interventional model
Masking
792 participants in 1 patient group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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