Chromoendoscopy or Narrow Band Imaging (NBI) for Improving Adenoma Detection in Colonoscopy

Indiana University

Status: Withdrawn

Conditions: Colorectal Neoplasms

Treatments: Other: High definition white light endoscopy; Other: Chromoendoscopy; Device: Narrow band imaging

Study type: Interventional

Funder types: Other

Identifiers

NCT04192929

1912241137

Details and patient eligibility

About

Narrow band imaging or electronic chromoendoscopy might provide similar adenoma detection capabilities while limiting time spent when compared to conventional chromoendoscopy method.

Sex: All

Ages: 40+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Age ≥ 40 years
2. Referral for screening, surveillance or diagnostic colonoscopy

Exclusion criteria

1. Inflammatory bowel disease
2. History of colorectal cancer or colon resection
3. Indication of positive FIT or cologuard
4. Any colorectal cancer syndromes (FAP, HNPCC, SPS)
5. Patient with poor bowel preparation identified during insertion

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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0 participants in 3 patient groups, including a placebo group

High definition white light endoscopy

Placebo Comparator group

Description:

colonoscopy performed using high definition equipment

Treatment:

Other: High definition white light endoscopy

Chromoendoscopy

Active Comparator group

Description:

indigo carmine is sprayed on the colon mucosa during withdrawal phase

Treatment:

Other: Chromoendoscopy

Narrow band imaging

Experimental group

Description:

Narrow band imaging is used during withdrawal phase

Treatment:

Device: Narrow band imaging