Chronic Heart Failure - Cheyne Stokes Respiration - CS2 (3C-study)

University of Oslo

Status: Completed

Conditions: Heart Failure; Cheyne Stokes Respiration

Treatments: Other: without Autoset CS2; Device: ASV

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00563693

1.2007.980

Details and patient eligibility

About

An investigation where patients with chronic heart failure and cheyne stokes respiration, treated with adapitve servo ventilator, will improve their cardiac function and quality of life.

Full description

Chronic heart failure (HF) is one of the most important public health problems in cardiovascular medicine.

Several patients with chronic heart failure also has Cheyne Stokes respiration pattern. Earlier studies have shown that this respiration pattern improves with Adaptive servo ventilator. We wish to investigate wether this leads to improved cardiac function.

Enrollment: 40 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ejection fraction <40%
• NYHA class III-IV
• Optimized therapy with drugs
• Cheyne stokes respiration pattern > 25% while sleeping
• Age < 85 years
• clinical stability the last month before inclusion.

Exclusion criteria

• CABG less then 6 months ago
• PCI treatment less then 3 months ago
• Unstable angina pectoris
• Acute coronary syndrome less then 3 months ago
• Stroke less then 6 weeks ago
• Thoracal myopathy
• Advanced COPD

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

A

Experimental group

Description:

The patients use ASV

Treatment:

Device: ASV

Other: without Autoset CS2

B

Active Comparator group

Description:

Patients without ASV

Treatment:

Other: without Autoset CS2