Chronic Hepatitis C and Insulin Resistance

Garvan Institute of Medical Research

Status: Completed

Conditions: Hepatitis C; Insulin Resistance

Study type: Observational

Funder types: Other

Identifiers

NCT00707603

H04/126

Details and patient eligibility

About

Chronic hepatitis C (CHC) is among the commonest chronic infectious disease in Australia with >200,000 exposed persons. Amongst non-infectious chronic conditions- Type 2 diabetes, obesity and heart disease are extremely common. This study will examine the relationship between insulin resistance, fat deposition in the liver, muscle and abdomen, and liver injury due to CHC

Enrollment: 50 patients

Sex: Male

Ages: 25 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Caucasian male
• Age: 25-55 years
• Chronic Hepatitis C (PCR positive) and fibrosis ≤ F2 (if liver biopsy done)
• Genotypes 1 or 3
• Due to commence antiviral therapy
• BMI < 30

Exclusion criteria

• Cirrhosis or F3 fibrosis on liver biopsy (if done)
• > 20 g ETOH per day
• Type 2 Diabetes (need an OGTT if fasting BGL> 5.7)
• Concurrent HIV
• Other cause of liver disease

Trial design

50 participants in 2 patient groups

Hepatitis C subjects

Description:

Due to start therapy for Hepatitis C

Controls

Description:

Healthy males