Chronic Kidney Disease in Pregnant Females

Assiut University

Status: Not yet enrolling

Conditions: CKD

Treatments: Other: Participants are not assigned an intervention as a part of the study

Study type: Observational

Funder types: Other

Identifiers

NCT06738069

CKD in pregnancy

Details and patient eligibility

About

Screening of Chronic Kidney Disease among pregnant women for early detection

Full description

Normal pregnancy associated with plasma volume expansion and hormonal changes lead to an increase in GFR of 40% to 65% in first and second trimester , with decrease in GFR of approximately 15% to 20% in the third trimester . Chronic Kidney Disease (CKD) is defined as abnormalities of kidney structure or function, present for a minimum of 3 months, with significant health implications .CKD classification is based on Cause, GFR category (G1-G5), and Albuminuria category (A1-A3), abbreviated as CGA . CKD during pregnancy is a major health concern ,affecting up to 3% of women of reproductive age in high-income countries, but estimated prevalence may be as much as 50% higher in low and middle-income countries (LMICs). Pregnant women with CKD at high risk of adverse maternal and fetal outcome , including hypertension development or worsening ,Preeclampsia, eclampsia , Anemia , platelets abnormalities , worsening kidney function ,need for cesarean section ,Pregnancy loss ,stillbirth ,Preterm labor ,Intrauterine growth restriction . CKD if detected and treated early in its course, ESRD is often preventable, especially for high risk individuals. CKD is often unrecognizable and asymptomatic until it is in its later stages, when the chances of preventing kidney failure are limited. Therefore, in order to administer targeted therapeutic interventions . early identification and stratification of those at highest risk of CKD are urgently needed. Screening programs using state of the art point-of-care testing equipment with blood and urine samples can test for CKD both quickly and accurately

Enrollment: 497 estimated patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• -all pregnant women at antenatal care who came to Outpatient clinic at the Women's Health Hospital and Nephrology Outpatient Clinic at Assiut University Hospitals
• At age of 18 yrs old or above . -Who accept to participate with this study

Exclusion criteria

• Pregnant women who are known CKD.
• Pregnant women refuse to participate with this study .
• Pregnant women with Acute Kidney Injury .

Trial design

497 participants in 2 patient groups

Pregnant female with CKD

Description:

Pregnant female Newly discovered as chronic kidney disease by our study.inclusion criteria including age 18 or above who accept to precipitate this study.. exclusion criteria including female actually known as CKD and female refusing to precipitate in our study... this female confirmed as CKD by positive Alb/Cr ratio in 2 occasions with 3 months duration in between

Treatment:

Other: Participants are not assigned an intervention as a part of the study

Healthy pregnant female

Description:

Pregnant female without ckd and Alb /Cr ratio was negative

Treatment:

Other: Participants are not assigned an intervention as a part of the study