Chronic Mycoprotein Consumption and Nucleotide Content in Metabolic Health (MYTH)

University of Exeter

Status: Completed

Conditions: Healthy

Treatments: Other: Animal protein based diet; Other: Low-nucleotide mycoprotein based diet; Other: High-nucleotide mycoprotein based diet

Study type: Interventional

Funder types: Other

Identifiers

NCT02984358

660065613

Details and patient eligibility

About

Compare chronic (one week) of a 'normal' meat diet with one week of mycoprotein consumption, with or without a reduced nucleotide content, on markers of metabolic health, such as uric acid concentrations, blood glucose control and blood lipid profiles.

Enrollment: 30 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI between 18 and 30

Exclusion criteria

• On medication (except contraception)
• Smokers
• Diagnosed with any metabolic or cardiovascular conditions
• BMI < 18 or > 30
• Dietary restrictions (vegetarians/vegans, etc.)

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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30 participants in 3 patient groups, including a placebo group

Animal protein based diet

Placebo Comparator group

Description:

Seven day fully controlled normocaloric diet (1.2 g/ kg body weight of protein per day), with the main protein source at the two main meals (lunch and dinner) being provided by animal products (meat and fish).

Treatment:

Other: Animal protein based diet

Low-nucleotide mycoprotein based diet

Active Comparator group

Description:

Seven day fully controlled normocaloric diet (1.2 g/ kg body weight of protein per day), with the main protein source at the two main meals (lunch and dinner) being provided by nucleotide-depleted mycoprotein products (commercial Quorn products).

Treatment:

Other: Low-nucleotide mycoprotein based diet

High-nucleotide mycoprotein based diet

Active Comparator group

Description:

Seven day fully controlled normocaloric diet (1.2 g/ kg body weight of protein per day), with the main protein source at the two main meals (lunch and dinner) being provided by nucleotide-rich mycoprotein products.

Treatment:

Other: High-nucleotide mycoprotein based diet