Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis

Centre Hospitalier Universitaire de Nice

Status: Completed

Conditions: Aggressive Periodontitis; Presence / Absence of EBV; Chronic Periodontitis

Treatments: Procedure: dental root planing

Study type: Interventional

Funder types: Other

Identifiers

NCT01246596

10-AOI-01

Details and patient eligibility

About

The etiopathogenesis of periodontal disease results from complex interaction between infectious agents, mainly including bacteria, and host cellular and humoral immune responses. However it is thought that bacteria-induced pathogenesis is not sufficient alone to explain all biological and clinical features of the destructive periodontal disease. The main hypothesis is that herpesviruses, such as Epstein-Barr Virus, may participate as well by altering epithelial gingival cell biology and consequently may promote the initiation and progression of periodontitis.

Enrollment: 23 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 10 patients affected by chronic periodontitis
• 10 patients affected by aggressive periodontitis
• 10 healthy patients (orthodontics extraction)
• Subject who have read and understood the information note relative under investigation and who have signed the informed consent
• major patient

Exclusion criteria

• Patient with no contre-indication to periodontal treatment
• Patient with serious blood disease
• Patient who exhibits systemic condition incompatible with realization of the study
• Patient treated with oral retinoids, bisphosphonates, oral anticoagulants and anticonvulsivants
• Patient who presents a buccal carcinoma treated with radiotherapy
• Patient who have received during the past 6 months: anti-inflammatory drugs, anti-cancerous or immunosuppressive chemiotherapy
• Patient who presents a linguistic or psychic incapacity to understand information

Trial design

Primary purpose: Health Services Research

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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23 participants in 3 patient groups

chronic periodontitis

Active Comparator group

Treatment:

Procedure: dental root planing

Procedure: dental root planing

Procedure: dental root planing

aggressive periodontitis

Active Comparator group

Treatment:

Procedure: dental root planing

Procedure: dental root planing

Procedure: dental root planing

healthy patient (orthodontics extraction)

Active Comparator group

Treatment:

Procedure: dental root planing

Procedure: dental root planing

Procedure: dental root planing