Chronic Presence of Epstein Barr Virus in Sulcular and Junctional Epithelial Tissue From Gingiva is Associated With Severe Periodontitis

Centre Hospitalier Universitaire de Nice

Status: Completed

Conditions: Parodontitis Aggressive; Parodontitis Chronic

Treatments: Procedure: Biopsy; Procedure: biopsy

Study type: Interventional

Funder types: Other

Identifiers

NCT01246648

10-PP-13

Details and patient eligibility

About

The etiopathogenesis of periodontal disease results from complex interaction between infectious agents, mainly including bacteria, and host cellular and humoral immune responses. However it is thought that bacteria-induced pathogenesis is not sufficient alone to explain all biological and clinical features of the destructive periodontal disease. The main hypothesis is that herpesviruses, such as Epstein-Barr Virus, may participate as well by altering epithelial gingival cell biology and consequently may promote the initiation and progression of periodontitis.

Enrollment: 6 patients

Sex: Male

Ages: 12+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Men exclusively
• 12 years minimum
• 2 patients affected by chronic periodontitis
• 2 patients affected by aggressive periodontitis
• 2 healthy patients (orthodontics extraction)
• Subject who have read and understood the information note relative under investigation and who have signed the informed consent
• Subject whose legal representative signed the parental consent (if minor patient)

Exclusion criteria

• Patient with contre-indication to dental extraction
• Patient witn serious blood disease
• Patient who exhibits systemic condition incompatible with the realization of the study
• Patient treated with oral retinoids, bisphosphonates, oral anticoagulants and anticonvulsivants
• Patient who presents za buccal carcinoma treated with radiotherapy
• Patient who have received during the past 6 months: anti-inflammatory drugs, anti-cancerous or immunosuppressive chemiotherapy
• Patient who presents a linguistic or psychic incapacity to understand information
• Female patient

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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6 participants in 3 patient groups

chronic periodontitis

Active Comparator group

Treatment:

Procedure: Biopsy

Procedure: Biopsy

agressive periodontitis

Active Comparator group

Treatment:

Procedure: biopsy

healthy patients

Active Comparator group

Treatment:

Procedure: Biopsy

Procedure: Biopsy