Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Incidence in Patients With Central Versus Peripheral Embolism

University of Cologne

Status: Unknown

Conditions: CTEPH

Study type: Observational

Funder types: Other

Identifiers

NCT01672203

UKK-PostLE

Details and patient eligibility

About

Chronic thromboembolic pulmonary hypertension (CTEPH) has been associated with increased morbidity and mortality. Patients with pulmonary embolism (PE) have elevated risk for development of CTEPH. It is not known, whether the location of pulmonary embolism (central vs. peripheral) nor fibrinolysis have an impact of CTEPH incidence. This study has been performed to assess the CTEPH incidence in different populations: in patients with central vs. peripheral PE and in patients with or without fibrinolysis therapy for PE.

Full description

The embolus localization during index pulmonary embolism might be of potential relevance for CTEPH development.

In the present study patients with confirmed pulmonary embolism for at least 12 months will be screened for CTEPH. The incidence of CTEPH will be correlated to thrombus location (central vs. peripheral) and the index use of fibrinolysis.

Enrollment: 500 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• acute pulmonary embolism for at least 12 months

Exclusion criteria

• known pulmonary hypertension other than CTEPH

Trial design

500 participants in 4 patient groups

PE peripheral with fibrinolysis

Description:

Patients with peripheral PE who received fibrinolysis therapy

PE peripheral, no fibrinolysis

Description:

Patients with peripheral PE who did not receive fibrinolysis

PE central with fibrinolysis

Description:

Patients with central PE who received fibrinolysis therapy

PE central, no fibrinolysis

Description:

Patients with central PE who did not receive fibrinolysis