Chronotropic Incompetence During Exercise Testing in Obese Adolescents

Hasselt University

Status: Unknown

Conditions: Cardiac Disease; Obesity, Childhood; Cardiovascular Risk Factor

Treatments: Diagnostic Test: The prevalence of chronotropic incompetence during maximal cardiopulmonary exercise testing

Study type: Observational

Funder types: Other

Identifiers

NCT04185753

CIDCET study

Details and patient eligibility

About

In adolescents with obesity cardiopulmonary exercise testing (CPET) has become an important clinical examination providing valuable information with regard to the integrative exercise responses, including the pulmonary, cardiovascular and muscular systems.

During CPET, mechanical constraints in ventilation, an elevated risk for hypoxia and chronotropic incompetence (CI) (defined as the inability of the heart to increase its rate with increased activity), or compromised cardiac function (e.g. lowered heart rate (HR) recovery, chronotropic index and stroke volume) are often observed in obese adults. Moreover, several studies regarding exercise capacity and cardiopulmonary responses to maximal endurance exercise testing have been performed in obese adolescents. Despite these previous investigations in obese adolescents it remains controversial whether cardiopulmonary disturbances can be observed consistently during CPET. However, a number of studies have reported a suboptimal response to exercise, in particular a reduced peak heart rate (HRpeak) and peak cycling power output (Wpeak). Adult obesity modifies cardiac behavior, including resting HR and CI, which has a marked effect on exercise capacity. Therefore, chronotropic variables are the most important factors that affect exercise performance. It has been shown that both peak and resting HR account for over forty percent of variability of exercise capacity. Interestingly, resting HR and HR response to exercise, including a blunted HR increase, low chronotropic index and HR recovery, are important predictors of all-cause mortality and cardiovascular death, at least in adults. These changes in HR during and recovery from CPET are mediated by the balance between sympathetic and vagal activity of the autonomic nervous system. Adverse cardiovascular outcomes associated with the metabolic syndrome may be mediated by autonomic dysfunction, whereby obesity is characterized by sympathetic predominance and a decrease in vagal activity in the basal state, where reduced sympathetic responsiveness has been observed during exercise. Therefore, these multiple exercise risk markers could provide valuable clinical information regarding cardiometabolic health. Nonetheless HR behavior during CPET has not been described in obese adolescents. The goal of this study is to examine the HR behavior of obese adolescents during CPET to clarify whether this population suffer from CI.

Enrollment: 60 estimated patients

Sex: All

Ages: 11 to 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• obese or lean (based on extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity)
• Parental permission

Exclusion criteria

• Chronic cardiovascular, renal, pulmonary or orthopaedic disease
• Medication use that could possibly influence the heart rate

Trial design

60 participants in 2 patient groups

Obese adolescents with CI

Description:

Obese adolescents with chronotropic incompetence

Treatment:

Diagnostic Test: The prevalence of chronotropic incompetence during maximal cardiopulmonary exercise testing

Control group

Description:

Obese adolescents without chronotropic incompetence

Treatment:

Diagnostic Test: The prevalence of chronotropic incompetence during maximal cardiopulmonary exercise testing