CI-AKI in Patients With Stable CAD and Comorbidities. Are we Doing Better?

I.M. Sechenov First Moscow State Medical University

Status: Completed

Conditions: Stable Angina; Acute Kidney Injury; Contrast-induced Nephropathy

Treatments: Procedure: Iodinated contrast media

Study type: Observational

Funder types: Other

Identifiers

NCT04014153

1/13 (Other Grant/Funding Number)

Details and patient eligibility

About

Patients aged 18-89 with stable CAD and comorbidities receiving optimal medical treatment requiring PCI with iodinated contrast media.

The aim of the study is to assess the prevalence of contrast-induced AKI in 2012-2013 and 2017 cohorts and to evaluate the potential risk factors of CI-AKI to better guide the prevention in patients of higher risk.

Enrollment: 1,023 patients

Sex: All

Ages: 18 to 89 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Informed consent
• Male and female patients 18 y. o. and older
• Verified stable coronary artery disease (CAD)
• Receiving optimal medical treatment and requiring percutaneous coronary intervention (PCI) with iodinated contrast media

Exclusion criteria

• Pregnancy, lactation
• Conditions affecting the prognosis (kidney failure, liver failure, oncology)
• Acute coronary syndrome (ACS)
• Stroke
• Contraindications to PCI
• Therapy with nephrotoxic drugs during the enrolment which cannot be stopped
• Refusal to sign the informed consent

Trial design

1,023 participants in 2 patient groups

Group 1 (5-year prognosis)

Treatment:

Procedure: Iodinated contrast media

Group 2 (1-year prognosis)

Treatment:

Procedure: Iodinated contrast media