Ciprofloxacin in Drug-resistant Epilepsy (CIDRE)

Mazandaran University of Medical Sciences

Status

Completed

Conditions

Epilepsy Intractable

Treatments

Drug: Ciprofloxacin Oral Product

Study type

Interventional

Funder types

Other

Identifiers

NCT04763070

5210

Details and patient eligibility

About

This study aims to investigate the effect of a short-term prescription of ciprofloxacin on intestinal microbial pattern and seizure frequency of patients with drug-resistant epilepsy.

Enrollment

23 patients

Sex

All

Ages

16 to 50 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Drug-resistant epilepsy with frequency of at least 2 seizure/Week
Acceptance of patients or his/her guardian (Signing informed consent)

Exclusion criteria

Hypersensitivity to ciprofloxacin or other fluoroquinolones
History of tendon, renal, hepatic or cerebrovascular disease, organ transplantation or myasthenia gravis
Usage of medications with interaction to ciprofloxacin
No reliable contraception
Pregnancy or breastfeeding
Being under treatment with corticosteroid
Usage of antibiotics in recent 2 months or need to use it during the study
Patients who are candidate for epilepsy surgery or other nonmedical treatments
Change in anti-seizure medications (ASMs) during recent month
Patients who will need changes in ASMs dose during study