Ciprofol Sedation in Patients Undergoing Liver Cancer Percutaneous Radiofrequency Ablation

University of Chinese Academy Sciences

Status: Enrolling

Conditions: Ciprofol; Liver Cancer

Treatments: Drug: Ciprofol; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT06178926

IRB-2023-350

Details and patient eligibility

About

Efficacy and Safety of Ciprofol Sedation in Patients Undergoing Liver Cancer Percutaneous Radiofrequency Ablation

Full description

Ciprofol was injected before ablation and sedation scores were measured to make sure certain sedation.

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who intend to undergoing ultrasound-guided percutaneous radiofrequency ablation of liver tumors;
• Age: 18-75 years old;
• ASA grade I-III;
• Laboratory examination meets the following conditions: neutrophils >1.5×109/L, platelet >80×109/L, hemoglobin >90g/L, aspartate transferase <1.5×ULN, total bilirubin <1.5×ULN, serum creatinine <1.2 x ULN;
• Chemotherapy < 4 times.

Exclusion criteria

• Patients who are known to be allergic to propofol, opioids, eggs, soy products, or patients who are contraindicated with these drugs or foods due to illness;
• serious organ dysfunction and other systemic diseases, such as liver dysfunction, renal dysfunction; Worsening congestive heart failure within the last 6 months resulting in hospitalization or adjustment of medication; Severe aortic or mitral stenosis; Heart surgery (heart valve replacement) within the last 6 months; Acute myocardial infarction in the last 6 months; Hemodynamic disturbance due to arrhythmia; Respiratory diseases; Cerebrovascular diseases; . Taking propofol, opioids or other analgesic and sedative drugs 72 hours before . Emergency surgery;
• Those who are unable to communicate with the researcher normally or who are deemed unsuitable by the researcher and refuse to participate in the study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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80 participants in 2 patient groups

Propofol

Active Comparator group

Description:

Use propofol for sedation during anesthesia.

Treatment:

Drug: Propofol

Ciprofol

Experimental group

Description:

Use ciprofol for sedation during anesthesia

Treatment:

Drug: Ciprofol