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Circadian as A Prognostic Factor For Radiation Response in Cervical Cancer

U

University of Indonesia (UI)

Status

Completed

Conditions

Radiotherapy Side Effect
Cervical Cancer

Treatments

Radiation: Afternoon Radiation

Study type

Interventional

Funder types

Other

Identifiers

NCT05511740
27/PT02.FK/ETIK/2010

Details and patient eligibility

About

The study was a Randomized Clinical Trial (RCT) or clinical trial comparing the results of radiation treatment of 2 treatment groups, i.e. subject groups irradiated in the morning and in the afternoon, to check melatonin levels in cervical cancer patients. Since it is known that the function of melatonin is as an antiproliferation substance or hormone, induces apoptosis, inhibits invasion and metastasis.

Enrollment

71 patients

Sex

All

Ages

25 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • cervical cancer patients stage IIB-IIIB (FIGO)
  • no previous treatment
  • histopathologic examination results of squamous cell carcinoma (SCC)
  • KPS > 70 with levels of Hb > 10 g%,

Exclusion criteria

  • Distant metastasis and locally spread to the adjacent healthy tissue (urinary bladder or rectum).

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

71 participants in 2 patient groups

Morning Radiation
No Intervention group
Afternoon Radiation
Active Comparator group
Treatment:
Radiation: Afternoon Radiation

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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