Circadian Modulation of Grape Consumption and Oxidative Stress Response

Idaho State University

Status

Completed

Conditions

Oxidative Stress

Treatments

Other: Grape

Study type

Interventional

Funder types

Other

Identifiers

NCT05873530

IRB-FY2021-264

Details and patient eligibility

About

This study investigated the effects of time-of-day of grape consumption on high-fat meal-induced oxidative stress.

Full description

Grape consumption acts on the immune system to produce antioxidant and anti-inflammatory effects. Since immune activity demonstrates circadian rhythmicity, with peak activity occurring during waking hours, the timing of grape intake may influence the magnitude of its antioxidant effect. This study followed a 2 x 2 factorial randomized, controlled design wherein healthy men and women (n = 32) consumed either a grape or placebo drink with a high-fat meal in the morning or evening. Urine was collected for measurements of biomarkers of oxidative stress and grape metabolites at baseline and post-meal at hour 1 and hours 1-6

Enrollment

32 patients

Sex

All

Ages

18 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy
Age 18-50 y

Exclusion criteria

Employed in shift or night work
Extreme early or late chronotype
Presence of acute infection or chronic inflammatory disease
Smoking
Heavy aerobic exerciser
Greater than moderate alcohol intake
Pregnancy or lactation
Use of non-steroidal anti-inflammatory medications or antioxidant dietary supplements.