Circadian Rhythms and Cardiovascular Risk

Oregon Health & Science University (OHSU)

Status: Completed

Conditions: Obstructive Sleep Apnea

Treatments: Behavioral: Forced Desynchrony

Study type: Interventional

Funder types: Other

Identifiers

NCT02202811

OSA 00010101

Details and patient eligibility

About

The purpose of this study is to understand how behaviors and the effects of the body's internal clock (called the circadian pacemaker) affect the control of the heart and blood pressure.

People with Obstructive Sleep Apnea (OSA) are hypothesized to have altered circadian amplitudes in certain key indices of cardiovascular (CV) and an abnormally advanced circadian phase in some of the same key indices of CV risk. The investigators hypothesize that such changes, taken together, may explain the different timing of heart attack and sudden cardiac death in OSA.

Enrollment: 39 patients

Sex: All

Ages: 40 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

• BMI less than 40
• Moderate to severe OSA (AHI)>15
• No current or previous pharmacological treatment for hypertension

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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39 participants in 2 patient groups, including a placebo group

Obstructive Sleep Apnea

Experimental group

Description:

Forced Desynchrony, OSA

Treatment:

Behavioral: Forced Desynchrony

Control

Placebo Comparator group

Description:

Forced Desynchrony, Control

Treatment:

Behavioral: Forced Desynchrony