Circadian Rhythms in Patients With IBD or Celiac Disease Upon Diagnosis and Medical Follow-up

Tel Aviv Sourasky Medical Center

Status: Completed

Conditions: Circadian Dysregulation; Inflammatory Bowel Diseases

Treatments: Other: no intervention performed- observational only

Study type: Observational

Funder types: Other

Identifiers

NCT03662646

TASMAC-16-YW-0200-CTIL

Details and patient eligibility

About

patients 6-25 years old upon diagnostic evaluation will be recruited . study population will comprise of two groups: newly diagnosed IBD patients/ Celiac disease and healthy controls.

upon enrollment, subjects will fill out sleeping habits questioners, demographic data, medical history.

blood samples will be drawn for CRP and clock gene expression in systemic WBC. intestinal biopsies will be snap frozen for clock gene extraction and amplification only for patients with IBD.

Enrollment: 80 patients

Sex: All

Ages: 6 to 25 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• IBD or celiac patients with a confirmed diagnosis, recruited upon diagnosis.
• Both male and female
• Age 6-25 years
• Medically treated for IBD in our institute.

Exclusion criteria

• Genetic disorder.
• Known primary or secondary immunodeficiency .
• Pregnancy or lactating

Trial design

80 participants in 2 patient groups

IBD patients

Treatment:

Other: no intervention performed- observational only

Healthy controls

Treatment:

Other: no intervention performed- observational only