Circulating Exosomes and Endothelial Dysfunction in Patients With Obstructive Sleep Apneas Hypopneas Syndrome (EXODYS)

University Hospital, Angers

Status: Completed

Conditions: Endothelial Dysfunction

Treatments: Diagnostic Test: ENDOPAT

Study type: Interventional

Funder types: Other

Identifiers

NCT04459182

2020-A01855-34

Details and patient eligibility

About

Evaluation of miRNA contained in exosomes in obese and OSA patients with endothelial dysfunction evaluated by digital plethysmography (ENDOPAT) compared to obese and OSA patients without endothelial dysfunction.

Full description

The aim of the study is to compare the content of exosomes between two goups of 20 patients, with and without endothelial dysfucntion.

the endothelial function will be evaluated after polysomnography, on obese patients with OSA (AHI >15).

Enrollment: 99 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult subject
• Subject understands the study protocol and is willing and able to comply with study requirements and sign informed consent
• Subject with OSA (defined by AHI >15/h)

Exclusion criteria

• cardiac or vascular desease

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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99 participants in 2 patient groups

Endothelial dysfunction (DE+)

Active Comparator group

Description:

obsese patient with OSA (AHI\>15) and endothelial dysfunction

Treatment:

Diagnostic Test: ENDOPAT

No endothelial dysfunction (DE-)

Sham Comparator group

Description:

obsese patient with OSA (AHI\>15) and no endothelial dysfunction

Treatment:

Diagnostic Test: ENDOPAT