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Circulating Exosomes and Endothelial Dysfunction in Patients With Obstructive Sleep Apneas Hypopneas Syndrome (EXODYS)

U

University Hospital, Angers

Status

Completed

Conditions

Endothelial Dysfunction

Treatments

Diagnostic Test: ENDOPAT

Study type

Interventional

Funder types

Other

Identifiers

NCT04459182
2020-A01855-34

Details and patient eligibility

About

Evaluation of miRNA contained in exosomes in obese and OSA patients with endothelial dysfunction evaluated by digital plethysmography (ENDOPAT) compared to obese and OSA patients without endothelial dysfunction.

Full description

The aim of the study is to compare the content of exosomes between two goups of 20 patients, with and without endothelial dysfucntion.

the endothelial function will be evaluated after polysomnography, on obese patients with OSA (AHI >15).

Enrollment

99 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • adult subject
  • Subject understands the study protocol and is willing and able to comply with study requirements and sign informed consent
  • Subject with OSA (defined by AHI >15/h)

Exclusion criteria

  • cardiac or vascular desease

Trial design

Primary purpose

Basic Science

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

99 participants in 2 patient groups

Endothelial dysfunction (DE+)
Active Comparator group
Description:
obsese patient with OSA (AHI\>15) and endothelial dysfunction
Treatment:
Diagnostic Test: ENDOPAT
No endothelial dysfunction (DE-)
Sham Comparator group
Description:
obsese patient with OSA (AHI\>15) and no endothelial dysfunction
Treatment:
Diagnostic Test: ENDOPAT

Trial contacts and locations

1

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Central trial contact

GAGNADOUX Frédéric, PhD

Data sourced from clinicaltrials.gov

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