Circulating Extracellular Exosomal Small RNA as Potential Biomarker for Human Pancreatic Cancer

Huazhong University of Science and Technology

Status: Unknown

Conditions: Pancreas Adenocarcinoma

Treatments: Procedure: Venous sampling

Study type: Interventional

Funder types: Other

Identifiers

NCT04636788

E-sR2020

Details and patient eligibility

About

This study is for the verification of biomarkers for pancreatic cancer treatment using small RNA liquid biopsy, combined with EUS-FNA tissues.

Full description

CA19-9 is the FDA approved biomarker for the diagnosis of pancreatic cancer. However, the specificity of CA19-9 to differentiate between pancreatic cancer, cholangiocarcinoma, or other pancreatic lesions is not satisfying enough.

Tumor cells secret abundant exosomes in the early stage. Circulating tumor cells are detected mainly in the advanced stage. Meanwhile, the role of non-coding RNA draws more and more attention in tumor area. Exosomes protect inside RNA from plasma RNase. Compared with long RNA, small RNA, including miRNA, snoRNA, tRNA, piRNA could exist more stably.

By means of next-generation sequencing, we look forward to finding new exosomal small RNA biomarkers.

Enrollment: 102 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age >18
• pancreatic cancer patients
• pancreatic lesions other than PAAD
• chronic pancreatitis
• cholangiocarcinoma

Exclusion criteria

• diagnosed with other pathological types of cancer
• treated with chemo/radio/surgery previously

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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102 participants in 1 patient group

pancreatic cancer group

Other group

Description:

pancreatic cancer, anticipated participants: 68 other pancreatic lesions including MCN, SCN, IPMN, SPN without malignant pathological finding chronic pancreatitis cholangiocarcinoma healthy control anticipated participants: 34

Treatment:

Procedure: Venous sampling