Circulating microRNAs as Biomarkers of Sepsis

Naval Military Medical University

Status

Completed

Conditions

Sepsis

Study type

Observational

Funder types

Other

Identifiers

NCT00862290

microRNA_sepsis

Details and patient eligibility

About

MicroRNA has been demonstrated to play a crucial role in regulating cell processes. Recently, microRNA was identified to exist in human serum or plasma, and it might be related to certain diseases. Several microRNAs are involved in sepsis, such as miR-146, miR-155, and so on. But whether serum miR-146 is present in serum of septic patients remains unknown. The present study was designed to identify the existence of specific microRNAs, which might be new markers for sepsis and its prognosis.

Enrollment

100 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

patients who develop sepsis and undergo abdominal surgery
patients who develop SIRS after cardiac surgery with cardiopulmonary bypass

Exclusion criteria

patients with a primary diagnosis of acute pancreatitis
patients with cirrhosis or renal dysfunction
patients with dyscrasia
patients with autoimmunity diseases
patients with severe cardiac and pulmonary diseases
patients with hematological diseases
patients who had organ dysfunction after cardiac surgery with cardiopulmonary bypass