Circulatory Coherence in COVID-19 and Non-COVID-19 Patients With Sepsis

University Hospital Hradec Kralove

Status: Completed

Conditions: Viral Pneumonia; Sepsis

Treatments: Diagnostic Test: microcirculation recording

Study type: Observational

Funder types: Other

Identifiers

NCT04644302

FNHK_IGS_8144

Details and patient eligibility

About

This prospective observational pilot study investigates circulatory coherence in patients with COVID and non-COVID sepsis by comparison of microcirculation, endothelial glycocalyx, and clinical course

Full description

This prospective observational pilot study investigates circulatory coherence in patients with COVID and non-COVID sepsis by comparison of microcirculation (sublingual area video recordings and biochemical parameters of endothelial cells activation and damage) endothelial glycocalyx (sublingual area video recordings and biochemical parameter of glycocalyx degradation), and clinical course.

Enrollment: 28 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult
• ICU admission due to sepsis with organ failure
• need for organ support therapy (mechanical ventilation, CRRT, ECMO)
• clinical and/or laboratory signs of circulatory instability

Exclusion criteria

• family withdrawal/disagreement
• death within three days from ICU admission

Trial design

28 participants in 2 patient groups

non-COVID sepsis

Description:

Patients admitted to ICU with sepsis of non-COVID origin

Treatment:

Diagnostic Test: microcirculation recording

COVID sepsis

Description:

Patients admitted to ICU with sepsis of COVID origin

Treatment:

Diagnostic Test: microcirculation recording