Circumferential Section Pane Less Than 1 mm in Esophagectomy for Esophageal Cancer.

University Hospital, Gasthuisberg

Status: Unknown

Conditions: Esophageal Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT01959906

CRM<1mm

Details and patient eligibility

About

A suspicious circumferential resection margin (CRM), defined as tumor cells within 1 mm of the CRM, is still controversial. The aim of this study was to compare the clinical significance of a suspicious CRM to histologically positive (R1) and negative margin (R0) resections in patients with pT3 esophageal and GE-Junction tumors.

Full description

From our prospectively build database 923 consecutive pT3 patients operated between january 1990 and june 2013 were selected. CRM status in patients treated by surgery only (n = 747) or after neoadjuvant therapy (n = 176) was recorded prospectively after surgery.

Kaplan-Meier survival curves were generated, and factors affecting survival were assessed by Cox regression multivariate analysis.

Enrollment: 923 patients

Sex: All

Ages: 18 to 95 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• pathologic T3 tumours of esophagus or GEJ

Exclusion criteria

• pT other than pT3
• R2 resections

Trial design

923 participants in 3 patient groups

R0

Description:

Complete resection

R1

Description:

Incomplete resection, microscopical tumor residu left behind

CRM<1mm

Description:

complete resection (R0), however tumor spreads till less than 1 mm from the section pane.