Citalopram vs Clomipramine vs Placebo in Recurrent Depression

University of Aarhus

Status: Completed

Conditions: Depression

Treatments: Drug: Citalopram; Drug: Clomipramine; Drug: placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT01575158

DUAG-5

Details and patient eligibility

About

citalopram and clomipramine are better than placebo in preventing new episodes of depression in patients with recurrent depression

Enrollment: 59 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with recurrent depression
• Sustained response achieved (3 consecutive monthly ratings at the HDS below 13)after a treatment requiring index episode

Exclusion criteria

• Contraindications to study medications
• Pregnancy
• Substance abuse

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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59 participants in 3 patient groups, including a placebo group

citalopram

Experimental group

Description:

citalopram

Treatment:

Drug: Citalopram

clomipramnine

Active Comparator group

Description:

clomipramine

Treatment:

Drug: Clomipramine

placebo

Placebo Comparator group

Description:

placebo

Treatment:

Drug: placebo