Citrate Anticoagulation for Postdilution Hemofiltration (CIPOHA)

Heinrich-Heine University, Duesseldorf

Status: Unknown

Conditions: Acute Kidney Injury; Critical Illness

Treatments: Other: renal replacement therapy as clinically indicated

Study type: Observational

Funder types: Other

Identifiers

NCT03969966

2018-82

Details and patient eligibility

About

This study evaluates a protocol for regional citrate anticoagulation in critically ill patients with acute kidney injury who are treated with continuous veno-venous haemofiltration in postdilution mode.

Full description

Acute kidney injury (AKI) requiring continuous renal replacement therapy (CCRT occurs in approx. 15 % of all intensive care patients. A sustained and prolonged filter running time is required to deliver an effective dialysis dose. This requires effective anticoagulation. Today, regional citrate anticoagulation (RCA) is preferred over systemic anticoagulation because of prolonged filter lifetimes and less adverse effects.

We here study prospectively patients with AKI who are treated with continuous veno-venous haemofiltration using an RCA protocol.

We will evaluate all parameters of CRRT including filter running times, delivered dialysis dose, causes for treatment interruption and control of pH and electrolytes.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• acute kidney injury
• critical illness and treatment at ICU

Exclusion criteria

• age < 18 years
• pregnancy or breast feeding
• severe lactate acidosis ( > 10 mmol/l) for longer than 6 hours and pH < 7.2