Citrate Pharmacokinetics and Regional Citrate Anticoagulation in CRRT

Fudan University

Status: Unknown

Conditions: Hepatic Insufficiency; MODS; Acute Kidney Failure With or Without:; Sepsis

Study type: Observational

Funder types: Other

Identifiers

NCT00948558

KY2009-108

Details and patient eligibility

About

1. To compare the differences of citrate pharmacokinetics in healthy individuals and critically ill patients as well as the influential factors.
2. To validate a pharmacokinetic model which has been established in a formal paper.
3. To create a safe and effective RCA-CRRT protocol.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy individuals, none-pregnant
• diagnosed with acute renal failure according to RIFLE criteria
• ARF with hepatic insufficiency
• ARF with MODS or sepsis
• within informed consent

Exclusion criteria

• used drugs with citrate within one week
• infused with blood,plasma or platelet or undergone plasma exchange therapy within 48 hours
• serious alkalosis with PH>7.55
• serious lactic acidosis
• not in resuscitation state