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Citrate Versus Heparin Anticoagulation: Effect on Molecules Clearances (RCA-SHA)

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Civil Hospices of Lyon

Status

Unknown

Conditions

Septic Shock

Treatments

Drug: Anticoagulation to prevent clotting of the extracorporeal circuit. (regional citrate anticoagulation)
Drug: Anticoagulation to prevent clotting of the extracorporeal circuit (Unfractionated heparin)

Study type

Interventional

Funder types

Other

Identifiers

NCT01839578
2012.724

Details and patient eligibility

About

Sepsis is responsible for 50% of all acute kidney injury (AKI) in intensive care units (ICUs), contributing greatly to multiple organ dysfunction syndrome (MODS). Special types of continuous renal replacement therapies (CRRT) have been proposed as adjuvant therapies for septic shock due to their ability to remove middle molecular weight molecules such as inflammatory mediators involved in MODS pathophysiology. These therapies are called extracorporeal " blood purification " therapies.

When CRRT is used, an anticoagulation is required to prevent clotting of the extracorporeal circuit, possibly causing bleeding in selected patients. Many anticoagulation strategies have been proposed and the most commonly used in 2013 is still unfractionated heparin. Regional citrate anticoagulation (RCA) is an interesting alternative as it dramatically decreases the bleeding risk.

The investigators hypothesize that the use of citrate with Super High Flux Continuous Veno-Venus Hemodialysis (SHF-CVVHD) would be highly beneficial over time by preserving the filter effectiveness via limiting protein adhesion (which subsequently reduces filter pore sizes (protein cake)), as compared to heparin. Consequently, higher clearances of the inflammatory mediators could be maintained over time with citrate as compared to heparin anticoagulation. In other words, for the same duration of filter use, middle molecular weight molecules and cytokines clearances would be greater with citrate as compared to heparin. To test this hypothesis, the investigators will perform a clinical randomized controlled trial which aim would be to compare middle molecular weight molecules and cytokines clearances in SHF-CVVHD using RCA versus systemic heparin anticoagulation in septic patients with AKI.

Enrollment

30 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Male or female critically ill patients over the age of 18 years old
  • Acute Kidney Injury requiring CRRT defined using the Risk, Injury, Failure, Loss, End-stage renal disease (RIFLE) classification with criterion I or worse.
  • Septic shock as defined by the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference.
  • Written informed consent obtained from the patient or a patient's legal representative
  • Patient patient's legal representative able to agree to patient's enrollment in the study with informed consent.

Exclusion criteria

  • Pregnancy
  • Participation in another research study protocol
  • Known heparin induced thrombopenia or contraindication to heparin
  • Pre-existing chronic renal failure on chronic dialysis
  • Therapeutic anticoagulation with heparin for another reason (e.g. chonic arrhythmia)
  • Severe liver failure (15% prothrombin time)

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

30 participants in 2 patient groups

RCA Group
Experimental group
Description:
SHF-CVVHD with regional citrate anticoagulation
Treatment:
Drug: Anticoagulation to prevent clotting of the extracorporeal circuit. (regional citrate anticoagulation)
Heparin group
Experimental group
Description:
SHF-CVVHD with systemic heparin anticoagulation
Treatment:
Drug: Anticoagulation to prevent clotting of the extracorporeal circuit (Unfractionated heparin)

Trial contacts and locations

1

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Central trial contact

Pr Bernard Allaouchiche, Pr; Thomas Rimmelé, Dr

Data sourced from clinicaltrials.gov

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