CKD-581 + Bortezomib + Dexamethasone in Patients With Previously Treated Multiple Myeloma

C

Chong Kun Dang

Status and phase

Unknown
Phase 1

Conditions

Myeloma, Multiple

Treatments

Drug: CKD-581

Study type

Interventional

Funder types

Industry

Identifiers

NCT03051841
133MM16010

Details and patient eligibility

About

This study is to determine the maximum tolerated dose(MTD), dose limiting toxicity(DLT), safety and pharmacokinetics(PK) profile of a single agent CKD-581 injection in Combination with Bortezomib and Dexamethasone in patients with Previously Treated Multiple Myeloma.

Full description

This is an open label, dose escalation study. Cohort of 3~6 patients receive escalation doses of CKD-581 until the maximum toleated dose(MTD) is determined. The MTD is defiend as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose limiting toxicity.

Enrollment

18 estimated patients

Sex

All

Ages

19+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • must have received at least one prior lines of therapy and Diagnosis of symptomatic multiple myeloma(IMWG 2014)
  • Eastern Cooperative Oncology Group performance status ≤ 2
  • Life expectancy 12 weeks

must have the following laboratory values within 3 weeks prior to first dose of study drug

  • ANC(absolute neutrophil count) ≥ 1,500 mm3
  • PLT(platelet count)≥ 100,000 mm3
  • Hb ≥ 8.0g/dL
  • AST(SGOT) and ALT (SGPT) ≤ 3 x UNL(upper limit of normal)
  • Serum bilirubin ≤ 1.5 x ULN (but, Gilbert syndrome ≤ 3 x UNL)
  • Serum Cr ≤ 1.5 x UNL

One more measureable disease following values

  • Serum M-protein ≥ 1g/dL
  • Urine M-Protein ≥ 200mg/24hr
  • in that case serum M-protein, urine M-Protein nonmeasurable and FLC ratio abnormal, Serum FLC level ≥ 100mg/L(≥10mg/dL)
  • more than 24 weeks prior to last bortezomib dose
  • must have signed the consent form

Exclusion criteria

  • Patients with central neurological disease
  • Patients with clinically significant heart disease within 24weeks prior to first dose of study drug
  • patients with clinically significans abnormal EKG, echocardiography at screening
  • patients with active hepatitis, HIV positive(exception, non active hepatitis)
  • peripheral neuropathy ≥ CTCAE grade 2 or peripheral neuropathy ≥ CTCAE grade 1 with pain within 2 weeks prior to first dose of study drug
  • Patients with a prior malignancy with in the last 3 years except adequately treated basal cell or squamous cell or skin cancer, in situ cervical cancer
  • Patients who have received surgery, chemotherapy, radiation therapy or immunotherapy or any other investigational drugs ≤ 4 weeks prior to first dose of study drug and during treatment period
  • Women who are pregnant or breast feeding or women of childbearing potential not using an effective method of birth control. Male patients whose sexual partners are not using effective birth control.
  • patients with hypersensitive reaction of bortezomib or dexamethasone
  • patients without best overall response is above minimal response based on IMWG 2015 past all treatment for multiple myeloma
  • patients with refractory to past bortezomib treatment(ex; under minimal response) or progress within 60days prior to last bortezomib treatment

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

18 participants in 1 patient group

Treat Regimen
Experimental group
Description:
CKD-581(investigational Drug) Bortezomib Dexamethasone
Treatment:
Drug: CKD-581

Trial contacts and locations

0

Loading...

Central trial contact

Min Ji Song

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location

Resources

© Copyright 2024 Veeva Systems