CLAD: Finding Biomarkers to Predict Rejection and/ or Outcome After Lung Transplantation

Antwerp University Hospital (UZA)

Status: Terminated

Conditions: Primary Graft Dysfunction; Lung Transplant Failure and Rejection

Treatments: Other: blood and exhaled breath specimens

Study type: Observational

Funder types: Other

Identifiers

NCT04558333

CLAD

Details and patient eligibility

About

Lung transplantation is the ultimate treatment for end stage lung diseases. Survival after lung transplantation is limited mainly due to the development of chronic allograft dysfunction (CLAD). Both acute cellular rejection and primary grade dysfunction (PGD) have been associated with the development of CLAD. In this study we will investigate multiple prognostic factors that influence long term survival after lung transplantation with a specific interest in PGD, acute rejection and the development of CLAD.

Full description

At specific time points (according to protocol) exhaled breath, blood specimens, bronchoalveolar lavage and biopsies will be collected. These will be analyzed in an attempt to identify possible biomarkers that will predict the development of PGD and/or CLAD.

Enrollment: 24 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• all lung transplant recipients > 18 years signed ICF (informed consent form)

Exclusion criteria

• none

Trial design

24 participants in 1 patient group

LTx (lung transplant) patients

Description:

identification of possible biomarkers

Treatment:

Other: blood and exhaled breath specimens